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Acepromazine Rx
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Acepromazine |
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Our Price: $24.67 - $99.41 |
Acepromazine Rx, 10 mg, 100 Tablets
| SKU: |
ACE10100 |
| Price: $24.67 |
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Acepromazine Rx 10mg - 50ml
| SKU: |
ACE10x50 |
| Price: $27.80 |
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Acepromazine Rx, 10 mg x 500 Tablets
| SKU: |
ACE10500 |
| Price: $99.41 |
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| ACEPROMAZINE MALEATE Rx
For use in dogs only.
NADA 117-532, Approved by FDA
Caution:
Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
Description:
Acepromazine maleate, a potent neuroleptic agent with a low order of toxicity, is of particular value in the tranquilization of dogs. Its rapid action and lack of hypnotic effect are added advantages.
Chemistry:
2-acetyl-10-(3-dimethylaminopropyl) phenothiazine hydrogen maleate.
Acepromazine Maleate
Mode of Action:
Acepromazine maleate has a depressant effect on the central nervous system and therefore causes sedation, muscular relaxation and a reduction in spontaneous activity. It acts rapidly, exerting a prompt and pronounced calming effect. It is an effective preanesthetic agent and lowers the dosage requirement of general anesthetics.
Toxicology:
Acute and chronic toxicity studies have shown a very low order of toxicity for acepromazine maleate.
A safety study using elevated dosages of Acepromazine Maleate did not demonstrate adverse reactions even when administered at three times the upper limit of the recommended daily dosage (3.0 mg/lb of body weight). The clinical observation for this high dosage was mild depression which disappeared in most dogs 24 hours after termination of dosing.
The only occurrence of an adverse reaction during numerous clinical trials was a very mild respiratory distress (reverse sneeze) which was transient in nature and did not have an effect on the desired action of the drug.
Indications:
As an aid in tranquilization and as a pre-anesthetic agent in dogs.
Acepromazine Maleate can be used as an aid in controlling intractable animals during examination, treatment, grooming, x-ray and minor surgical procedures.
Contraindications:
Phenothiazines may potentiate the toxicity of organophosphates. Therefore, do not use acepromazine maleate to control tremors associated with organic phosphate poisoning.
Contraindications:
Phenothiazines may potentiate the toxicity of organophosphates and the activity of procaine hydrochloride. Do not use in conjunction with organophosphorus vermifuges or ectoparasiticides, including flea collars. Do not use with procaine hydrochloride.
Warning:
Not for use in animals intended for food.
Precautions:
Tranquilizers are potent central nervous system depressants and they can cause marked sedation with suppression of the sympathetic nervous system.
Tranquilizers can produce prolonged depression or motor restlessness when given in excessive amounts or when given to sensitive animals.
Tranquilizers are additive in action to the actions of other depressants and will potentiate general anesthesia. Tranquilizers should be administered in smaller doses and with greater care during general anesthesia and also to animals exhibiting symptoms of stress, debilitation, cardiac disease, sympathetic blockade, hypovolemia or shock. Acepromazine Maleate, like other phenothiazine derivatives, is detoxified in the liver; therefore, it should be used with caution in animals with a previous history of liver dysfunction or leukopenia.
Hypotension can occur after rapid intravenous causing cardiovascular collapse. Epinephrine is contraindicated for treatment of acute hypotension produced by phenothiazine-derivative tranquilizers since further depression of blood pressure can occur. Other pressor amines, such as norepinephrine or phenylephrine, are the drugs of choice.
In horses, paralysis of the retractor penis muscle has been associated with the use of phenothiazine-derivative tranquilizers. Such cases have occurred following the use of Acepromazine Maleate Injection. This risk should be duly considered prior to the administration of Acepromazine Maleate Injection to male horses (castrated and uncastrated). When given, the dosage should be carefully limited to the minimum necessary for the desired effect. At the time of tranquilization, it is not possible to differentiate between reversible protrusion of the penis (a normal clinical sign of narcosis) and the irreversible paralysis of the retractor muscle. The cause of this side reaction has not been determined. It has been postulated that such paralysis may occur when a tranquilizer is used in conjunction with testosterone (or in stallions).
Accidental intracarotid injection in horses can produce clinical signs ranging from disorientation to convulsive seizures and death.
Administration AND Dosage:
The dosage should be individualized, depending upon the degree of tranquilization required. As a general rule, the dosage requirement in mg/lb of body weight decreases as the weight of the animal increases.
Acepromazine Maleate Injection may be given intravenously, intramuscularly or subcutaneously. The following schedule may be used as a guide to IV, IM or SC injections:
Dogs: 0.25-0.5 mg/lb of body weight
Cats: 0.5-1 mg/lb of body weight
Horses: 2-4 mg/100 lb of body weight
IV doses should be administered slowly, and a period of at least 15 minutes should be allowed for the drug to take full effect.
How Supplied:
Each mL contains 10 mg acepromazine maleate. (Also contains sodium citrate 0.36%, citric acid 0.075%, benzyl alcohol 1% and Water for Injection, USP) in 50 mL vials. Store at controlled room temperature between 15° and 30°C (59° and 86°F). |
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