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Clindamycin Aquadrops Rx 25mg/20ml
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Advantage Multi Rx,
Advantage Multi Rx,
Prescription Required

Clindamycin Aquadrops Rx 25mg/20ml
See More from: Antirobe

Our Price: $7.00

SKU: CLINDAMYCN-DRPS
Price: $7.00 
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What is Clindamycin? Clindamycin is an antibiotic used to treat soft tissue, dental, and bone infections caused by susceptible strains of bacteria. Clindamycin requires a prescription from your veterinarian and is sold per capsule. Antirobe (brand of clindamycin hydrochloride) Capsules (for use in dogs only) are indicated for the treatment of infections. For: Cats and Dogs Benefits: • Effectively treats a wide variety of bacterial infections • Treats soft tissue infections • Treats bone and dental infections How it works: Clindamycin fights infections caused by susceptible bacteria. Clindamycin works by stopping the growth of bacteria. Cautions: Antibiotics can cause diarrhea. If the diarrhea is watery or has blood in it, call your veterinarian. Do not use any medication to stop the diarrhea unless instructed by your veterinarian. More Information: Brand Name Antirobe (Pharmacia and Upjohn), Antirobe Aquadrops (Pharmacia and Upjohn), Cleocin (Pharmacia) Generic Name Clindamycin (klin-da-my’-sin) What is the most important information I should know about Clindamycin: Do not use this medication if your pet is allergic to clindamycin or lincomycin (Bactramycin, L-Mycin, Lincocin). Do not give clindamycin together with erythromycin (E-Mycin, E.E.S., Ery-Tab, and others). Tell your veterinarian if your pet has kidney disease, liver disease, colitis, asthma, eczema, or allergic skin reaction. Give this medication for the entire length of time prescribed by your veterinarian. Symptoms may get better before the infection is fully treated. Antibiotics can cause diarrhea. If the diarrhea is watery or has blood in it, call your veterinarian. Do not use any medication to stop the diarrhea unless your veterinarian has told you to do so. Periodic blood testing will be necessary. Kidney and liver function may also need to be tested. Prior to any surgery on the pet, let your veterinarian know if your pet is still taking clindamycin. Clindamycin is FDA-approved for use in dogs only; however, it is a commonly accepted practice for veterinarians to use clindamycin in cats. Clindamycin is a prescription medication available as 25mg tablets, 150mg capsules and 25mg/ml liquid drops. What is Clindamycin: Clindamycin is an antibiotic that fights bacterial infections in the body. It is used to treat serious infections. Clindamycin may also be used for purposes other than those listed in this guide. ANTIROBE Capsules and ANTIROBE AQUADROPS Liquid contain clindamycin hydrochloride which is the hydrated salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chlorosubstitution of the 7(R)-hydroxyl group of a naturally produced antibiotic produced by Streptomyces lincolnensis var. lincolnensis. ANTIROBE Capsules (For Use in Dogs Only): 25 mg Capsule, each yellow and white capsule contains clindamycin hydrochloride equivalent to 25 mg of clindamycin. 75 mg Capsule, each green capsule contains clindamycin hydrochloride equivalent to 75 mg of clindamycin. 150 mg Capsule, each light blue and green capsule contains clindamycin hydrochloride equivalent to 150 mg of clindamycin. 300 mg Capsule, each light blue capsule contains clindamycin hydrochloride equivalent to 300 mg of clindamycin. ANTIROBE AQUADROPS Liquid (For Use in Dogs and Cats) is a palatable formulation intended for oral administration. Each mL of ANTIROBE AQUADROPS contains clindamycin hydrochloride equivalent to 25 mg clindamycin; and ethyl alcohol, 8.64%. What should I discuss with my veterinarian before giving Clindamycin to my pet: Do not use this medication if your pet is allergic to clindamycin or lincomycin (Bactramycin, L-Mycin, Lincocin). Do not give clindamycin together with erythromycin (E-Mycin, E.E.S., Ery-Tab, and others). Tell your veterinarian if your pet has kidney disease, liver disease, colitis, asthma, eczema, or allergic skin reaction. Tell your veterinarian if your pet is pregnant or lactating. How should this medication be given: Give this medication exactly as prescribed by your veterinarian. Do not give in larger amounts, or give for longer than recommended by your veterinarian. Follow the directions on the prescription label. Allow plenty of water for your pet to drink. Give this medication for the entire length of time prescribed by your veterinarian. Symptoms may get better before the infection is fully treated. Periodic blood testing will be necessary. Kidney and liver function may also need to be tested. Prior to any surgery on your pet, let your veterinarian know if your pet is still taking clindamycin. Store clindamycin at room temperature away from moisture and heat. What happens if I miss giving a dose: Give the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and give the next regularly scheduled dose. Do not give a double dose of the medication. What happens if I overdose the pet: Seek emergency veterinary medical attention if you think you have given your pet too much of this medication. Symptoms of clindamycin overdose may include vomiting, loss of appetite, weight loss, depression, behavior changes, or seizure. What should I avoid while giving Clindamycin to my pet: Antibiotics can cause diarrhea. If the diarrhea is watery or has blood in it, call your veterinarian. Do not use any medication to stop the diarrhea unless your veterinarian has told you to do so. What are the possible side effects of Clindamycin: If any of the following serious side effects occur, stop giving clindamycin and seek emergency veterinary medical help: an allergic reaction (hives; difficulty breathing; or swelling of the face, lips, tongue, or throat). Stop the medication and talk to your veterinarian if any of these side effects occur: diarrhea that is watery or bloody; fever; chills; body aches; nausea; stomach pain; loss of appetite; dark urine; jaundice; urinating less than usual or not at all; fever; headache; or blistering or peeling of the skin. Side effects other than those listed in this guide may occur. Talk to your veterinarian about any side effect that is unusual or especially bothersome to your pet. What other drugs will affect Clindamycin: There may be other drugs that can affect clindamycin. Tell your veterinarian about all prescription and over-the-counter medications you give your pet including vitamins, minerals, and herbal products. Where can I get more information: Your pharmacist has information written for health professionals that you can read. ACTIONS Site and Mode of Action: Clindamycin is an inhibitor of protein synthesis in the bacterial cell. The site of binding appears to be in the 5OS sub-unit of the ribosome. Binding occurs to the soluble RNA fraction of certain ribosomes, thereby inhibiting the binding of amino acids to those ribosomes. Clindamycin differs from cell wall inhibitors in that it causes irreversible modification of the protein-synthesizing subcellular elements at the ribosomal level. MICROBIOLOGY: Clindamycin is a lincosaminide antimicrobial agent with activity against a wide variety of aerobic and anaerobic bacterial pathogens. Clindamycin is a bacteriostatic compound that inhibits bacterial protein synthesis by binding to the 5OS ribosomal sub-unit. Absorption: Clindamycin hydrochloride is rapidly absorbed from the canine and feline gastrointestinal tract. Dog Serum Levels: Serum levels at or above 0.5 µg/mL can be maintained by oral dosing at a rate of 2.5 mg/lb of clindamycin hydrochloride every 12 hours. This same study revealed that average peak serum concentrations of clindamycin occur 1 hour and 15 minutes after oral dosing. The elimination half-life for clindamycin in dog serum was approximately 5 hours. There was no bioactivity accumulation after a regimen of multiple oral doses in healthy dogs. Clindamycin Serum Concentrations 2.5 mg/lb (5.5 mg/kg) After B.I.D. Oral Dose of Antirobe Capsules to Dogs Cat Serum Levels: Serum levels at or above 0.5 µg/mL can be maintained by oral dosing at a rate of 2.5 mg/lb of clindamycin hydrochloride every 24 hours. The average peak serum concentration of clindamycin occurs approximately 1 hour after oral dosing. The elimination half-life of clindamycin in feline serum is approximately 7.5 hours. In healthy cats, minimal accumulation occurs after multiple oral doses of clindamycin hydrochloride, and steady-state should be achieved by the third dose. Clindamycin Serum Concentrations 5 mg/lb (11 mg/kg) After Single Oral Dose of Antirobe Aquadrops to Cats METABOLISM AND EXCRETION Extensive studies of the metabolism and excretion of clindamycin hydrochloride administered orally in animals and humans have shown that unchanged drug and bioactive and bioinactive metabolites are excreted in urine and feces. Almost all of the bioactivity detected in serum after ANTIROBE product administration is due to the parent molecule (clindamycin). Urine bioactivity, however, reflects a mixture of clindamycin and active metabolites, especially N-demethyl clindamycin and clindamycin sulfoxide. ANIMAL SAFETY SUMMARY Rat and Dog Data: One year oral toxicity studies in rats and dogs at doses of 30, 100 and 300 mg/kg/day (13.6, 45.5 and 136.4 mg/lb/day) have shown clindamycin hydrochloride to be well tolerated. Differences did not occur in the parameters evaluated to assess toxicity when comparing groups of treated animals with contemporary controls. Rats administered clindamycin hydrochloride at 600 mg/kg/day (272.7 mg/lb/day) for six months tolerated the drug well; however, dogs orally dosed at 600 mg/kg/day (272.7 mg/lb/day) vomited, had anorexia, and subsequently lost weight. At necropsy these dogs had erosive gastritis and focal areas of necrosis of the mucosa of the gallbladder. Safety in gestating bitches or breeding males has not been established. Cat Data: The recommended daily therapeutic dose range for clindamycin hydrochloride (ANTIROBE AQUADROPS Liquid) is 11 to 33 mg/kg/day (5 to 15 mg/lb/day) depending on the severity of the condition. Clindamycin hydrochloride (ANTIROBE AQUADROPS Liquid) was tolerated with little evidence of toxicity in domestic shorthair cats when administered orally at 10x the minimum recommended therapeutic daily dose (11 mg/kg; 5 mg/lb) for 15 days, and at doses up to 5x the minimum recommended therapeutic dose for 42 days. Gastrointestinal tract upset (soft feces to diarrhea) occurred in control and treated cats with emesis occurring at doses 3x or greater than the minimum recommended therapeutic dose (11 mg/kg/day; 5 mg/lb/day). Lymphocytic inflammation of the gallbladder was noted in a greater number of treated cats at the 110 mg/kg/day (50 mg/lb/day) dose level than for control cats. No other effects were noted. Safety in gestating queens or breeding male cats has not been established. INDICATIONS ANTIROBE (brand of clindamycin hydrochloride) Capsules (for use in dogs only) and AQUADROPS Liquid (for use in dogs and cats) are indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below: Dogs: Skin infections (wounds and abscesses) due to coagulase positive staphylococci (Staphylococcus aureus or Staphylococcus intermedius). Deep wounds and abscesses due to Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Dental infections due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Osteomyelitis due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. Cats: Skin infections (wounds and abscesses) due to Staphylococcus aureus, Staphylococcus intermedius and Streptococcus spp. Deep wounds and infections due to Clostridium perfringens and Bacteroides fragilis. Dental infections due to Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp., Clostridium perfringens and Bacteroides fragilis. CONTRAINDICATIONS ANTIROBE Capsules and ANTIROBE AQUADROPS Liquid are contraindicated in animals with a history of hypersensitivity to preparations containing clindamycin or lincomycin. Because of potential adverse gastrointestinal effects, do not administer to rabbits, hamsters, guinea pigs, horses, chinchillas or ruminating animals. DOSAGE AND ADMINISTRATION Dogs: Infected Wounds, Abscesses and Dental Infections Oral: 2.5-15.0 mg/lb body weight every 12 hours Duration: Treatment with ANTIROBE products may be continued up to a maximum of 28 days if clinical judgment indicates. Treatment of acute infections should not be continued for more than three or four days if no response to therapy is seen. Dosage Schedule: Capsules ANTIROBE 25 mg, administer 1-6 capsules every 12 hours for each 10 pounds of body weight. ANTIROBE 75 mg, administer 1-6 capsules every 12 hours for each 30 pounds of body weight. ANTIROBE 150 mg, administer 1-6 capsules every 12 hours for each 60 pounds of body weight. ANTIROBE 300 mg, administer 1-6 capsules every 12 hours for each 120 pounds of body weight. Liquid ANTIROBE AQUADROPS, administer 1-6 mL/10 lbs body weight every 12 hours. Dogs: Osteomyelitis Oral: 5.0-15.0 mg/lb body weight every 12 hours. Duration: Treatment with ANTIROBE is recommended for a minimum of 28 days. Treatment should not be continued for longer than 28 days if no response to therapy is seen. Dosage Schedule: Capsules ANTIROBE 25 mg, administer 2-6 capsules every 12 hours for each 10 pounds of body weight. ANTIROBE 75 mg, administer 2-6 capsules every 12 hours for each 30 pounds of body weight. ANTIROBE 150 mg, administer 2-6 capsules every 12 hours for each 60 pounds of body weight. ANTIROBE 300 mg, administer 2-6 capsules every 12 hours for each 120 pounds of body weight. Liquid ANTIROBE AQUADROPS, administer 2-6 mL/10 lbs body weight every 12 hours. Cats: Infected Wounds, Abscesses, and Dental Infections 5.0 - 15.0 mg/lb body weight once every 24 hours depending on the severity of the condition. Duration: Treatment with ANTIROBE AQUADROPS Liquid may be continued up to a maximum of 14 days if clinical judgment indicates. Treatment of acute infections should not be continued for more than three to four days if no clinical response to therapy is seen.